Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

by

The concentrating on of each the muscarinic and β-adrenergic pathways is a effectively validated therapeutic strategy for the therapy of power obstructive pulmonary illness (COPD). On this communication we report our effort to include two pharmacologies right into a single chemical entity, whose attribute should be appropriate for a as soon as every day inhaled administration. Contextually, we aimed toward a domestically performing remedy with restricted systemic absorption to reduce negative effects. Our lung-tailored desing of bifunctional compounds that mix the muscarinic and β-adrenergic pharmacologies by the elaboration of the muscarinic inhibitor 7, efficiently led to the potent, pharmacologically balanced muscarinic antagonist and β2 agonist (MABA) 13.

Acute kidney harm (AKI) and power kidney illness are widespread interconnected syndromes that symbolize a public well being drawback. Acute kidney illness (AKD) is outlined because the post-AKI standing of acute or subacute kidney injury/dysfunction manifested by persistence of AKI past 7 to 90 days after the preliminary AKI analysis. Restricted scientific knowledge exist concerning AKD epidemiology however its incidence is noticed in ∼25% of AKI survivors. Helpful risk-stratification instruments to foretell danger of AKD and its prognosis are wanted. Interventions on fluid administration, nephrotoxic publicity, and follow-up care maintain promise to ameliorate the burden of AKD and its issues.

Affiliation between power kidney illness (CKD) and ischaemic coronary heart illness (IHD) is well-known. Clinically, due to using intra-arterial distinction, coronary angiograms are generally not carried out to keep away from additional deterioration in kidney operate amongst CKD sufferers. Due to this fact, our purpose is to establish whether or not intervention for non-ST elevation myocardial infarction (NStemi) is related to elevated mortality or additional renal deterioration. Power obstructive pulmonary illness (COPD) is usually accompanied by psychiatric issues, equivalent to despair and anxiousness, affecting each therapy outcomes and mortality. Proof for the variety of COPD sufferers utilizing remedy for these problems is sparse. On this examine, power antidepressant (ATD) and anxiolytic (ANX) drug use – to establish despair and anxiousness – amongst COPD sufferers was in contrast with topics with or with out different power illnesses.

Affiliation between the transtubular potassium gradient and development of power kidney illness: outcomes from KNOW-CKD

The transtubular potassium gradient which displays potassium secretion by the kidney by the cortical gathering duct, has not but been examined as a surrogate marker of kidney operate decline. Right here, we examine the connection between the transtubular potassium gradient and power kidney illness (CKD) development. We studied 1672 sufferers from the KoreaN Cohort Examine for Final result in Sufferers With Power Kidney Illness (KNOW-CKD) cohort. The transtubular potassium gradient was calculated utilizing a regular equation. The examine endpoint was CKD development, outlined as a composite of a ≥ 50% lower in estimated glomerular filtration fee (eGFR) from baseline values or end-stage kidney illness.
Throughout a median follow-up of 4.1 years (7149 person-years), 441 contributors reached the endpoint. In cause-specific competing danger evaluation, the best tertile was related to a considerably decrease danger of an opposed kidney consequence in contrast with the bottom tertile [hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.55-0.97]. When the transtubular potassium gradient was handled as a steady variable, a rise of 1 within the transtubular potassium gradient was related to a 6% decrease danger of CKD development (95% CI, 0.90-0.99). This affiliation was significantly evident in sufferers with an eGFR ≥ 45 mL/min/1.73 m2. A time-updated transtubular potassium gradient mannequin confirmed comparable outcomes.
The predictive efficiency of the transtubular potassium gradient was considerably lower than that of the eGFR, however much like that of proteinuria, serum bicarbonate, and urine osmolality.  The next transtubular potassium gradient is related to a considerably decrease danger of CKD development, suggesting that it might supply insights into the prognosis of CKD. Moreover, the serum ranges of FGF23 and Klotho are affected by numerous components, and the degrees of FGF23 and Klotho in CKD sufferers are negatively correlated. GFR, serum creatinine,
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

Significance of Power Illnesses and Smoking Habits within the Improvement of Acute Respiratory Misery Syndrome Amongst Hospitalized COVID-19 Sufferers in Indonesia

Acute respiratory misery syndrome (ARDS) is without doubt one of the important causes of excessive mortality amongst coronavirus illness 2019 (COVID-19) sufferers. This examine aimed toward figuring out the affiliation between presence of power illnesses and smoking behaviors with the event of ARDS amongst hospitalized COVID-19 sufferers in Indonesia. This examine was carried out in 15 Muhammadiyah-‘Aisyiyah-affiliated COVID-19 referral hospitals in Indonesia. 4 hundred ninety contributors who examined constructive for the COVID-19 had been recruited on this examine.

Demographic knowledge, historical past of power illnesses, and the event of ARDS had been retrieved from hospital affected person data. Details about the smoking conduct was collected after respondents had been discharged from the hospital. Presence of power illnesses equivalent to diabetes, power coronary heart illness, hypertension, and power liver illnesses had been considerably related to the event of ARDS. In an analogous regard, sufferers who at present smoked had a 5 occasions higher danger of creating ARDS in contrast with those that by no means smoked.

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNUB2035-500 500uL
EUR 513
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Concentration: 0.2mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNUB2046-100 100uL
EUR 264
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Concentration: 0.2mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNUB2046-50 50uL
EUR 405
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), 1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNUB2046-500 500uL
EUR 513
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Concentration: 0.2mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC552035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF555 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC552035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF555 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC552046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF555 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC552046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF555 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC612035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF660R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC612035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF660R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC612046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF660R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC612046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF660R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC472035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF647 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC472035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF647 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC472046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF647 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC472046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF647 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC042035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF405S conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC042035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF405S conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC042046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF405S conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC042046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF405S conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC052035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF405M conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC052035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF405M conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC052046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF405M conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC052046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF405M conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC402035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF640R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC402035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF640R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC402046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF640R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC402046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF640R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC432035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF543 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC432035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF543 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC432046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF543 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC432046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF543 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC702035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF770 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC702035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF770 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC702046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF770 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC702046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF770 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC802035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF680 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC802035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF680 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC802046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF680 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC802046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF680 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCH2035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCH2035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCH2046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCH2046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCP2035-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), PerCP conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCP2046-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), PerCP conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCR2035-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), RPE conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCR2046-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), RPE conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC942035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF594 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC942035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF594 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC942046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF594 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC942046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF594 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCA2035-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), APC conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCA2046-250 250uL
EUR 394
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), APC conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCB2035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Biotin conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCB2035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Biotin conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCB2046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Biotin conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCB2046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Biotin conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC882035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF488A conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC882035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF488A conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC882046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF488A conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC882046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF488A conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC682035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF568 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC682035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF568 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC682046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF568 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC682046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF568 conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCAP2035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNCAP2035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCAP2046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNCAP2046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC812035-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF680R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035) Antibody
BNC812035-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2035), CF680R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC812046-100 100uL
EUR 233
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF680R conjugate, Concentration: 0.1mg/mL

ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046) Antibody
BNC812046-500 500uL
EUR 545
Description: Primary antibody against ZAP70 (Chronic Lymphocytic Leukemia Marker) (ZAP70/2046), CF680R conjugate, Concentration: 0.1mg/mL

Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker) Monoclonal Antibody
M00754-1 100ug/vial
EUR 397
Description: Mouse Monoclonal ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody. Validated in IHC and tested in Human.

Monoclonal ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody, Clone: SPM362
APR14716G 7 ml
EUR 484
Description: A Monoclonal antibody against Human ZAP70 (Chronic Lymphocytic Leukemia Marker). The antibodies are raised in Mouse and are from clone SPM362. This antibody is applicable in IHC, IF, FC

Monoclonal ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody, Clone: 2F3.2
APR14717G 7 ml
EUR 484
Description: A Monoclonal antibody against Human ZAP70 (Chronic Lymphocytic Leukemia Marker). The antibodies are raised in Mouse and are from clone 2F3.2. This antibody is applicable in IHC, IF, FC

Cancer MicroRNA qPCR Array
RA610A-1 10 profiles
EUR 1172
  • Category: MicroRNA Tools

Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E02C1802-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E02C1802-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E02C1802-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monoclonal ZAP70 (Chronic Lymphocytic Leukemia Marker) Antibody, Clone: ZAP70/528
APR14715G 7 ml
EUR 484
Description: A Monoclonal antibody against Human ZAP70 (Chronic Lymphocytic Leukemia Marker). The antibodies are raised in Mouse and are from clone ZAP70/528. This antibody is applicable in IHC, IF, FC

Chronic Lymphocytic Leukemia Deletion Region Gene 8 Protein (CLLD8) Antibody
abx430501-200ul 200 ul
EUR 384
  • Shipped within 1-3 working days.

ZAP-70 (Chronic Lymphocytic Leukemia Marker); Clone ZAP70/528 (Concentrate)
RA0453-C.1 0.1 ml
EUR 125

ZAP-70 (Chronic Lymphocytic Leukemia Marker); Clone ZAP70/528 (Concentrate)
RA0453-C.5 0.5 ml
EUR 300

ZAP-70 (Chronic Lymphocytic Leukemia Marker); Clone ZAP70/528 (Concentrate)
RA0453-C1 1 ml
EUR 500

Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E03C1802-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E03C1802-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E03C1802-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E06C1802-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E06C1802-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E06C1802-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Goat Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E04C1802-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E04C1802-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E04C1802-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Rabbit Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E01C1802-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E01C1802-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) ELISA kit
E01C1802-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Human Chronic lymphocytic leukemia up regulated protein 1(CLLU1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Many sufferers with power fatigue syndrome (CFS) fail to derive profit from evidence-based remedies equivalent to cognitive-behavioural remedy (CBT) and graded train remedy resulting in everlasting incapacity. To find whether or not a repeat prescription of modafinil would possibly potentiate the advantages of CBT resulting in social restoration as outlined by 2 or extra level enchancment in vitality and muscular ache/focus and return to work or full-time coaching. Three sufferers with treatment-resistant CFS (imply length 17.66 years) handled with modafinil and CBT in a Liaison Psychiatry clinic had been retrospectively reviewed.